From the article:

“In healthy organisms, a surveillance system inside cells called chaperone-mediated autophagy (CMA) locates, digests and destroys damaged proteins. Specialised molecules, the “chaperones”, ferry the harmful material to membrane-bound sacs of enzymes within the cells known as lysosomes.

Once the cargo has been “docked”, a receptor molecule transfers the protein into the sac, where it is rapidly digested. With age, these receptors stop working as well, resulting in a dangerous build-up of faulty proteins that has been linked, in the liver, to insulin resistance as well as the inability to metabolise sugar, fats or alcohol

In genetically modified mice, Cuervo compensated for the loss of the receptors in the animals by adding extra copies.”

…

“That was enough to maintain a clean liver and to prove that if you keep your cells clean they work better,” she says.

…

“Research over the past decade has shown that restricted calorie intake in animals, including mammals, significantly enhances longevity.”

The fact that this is even possible is incredibly exciting.